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References:

  1. Keytruda Summary of Product Characteristics.
  2. Kantar Health. Treatment Architecture: Renal Cell Carcinoma.Cancer MPact®. EU5. 2020;1–89.

AE-RCC-00004 | Exp : 06 JUN 2024
AE-RCC-00003 | Exp : 06 JUN 2024
QA-RCC-00001 | Exp : 06 JUN 2024

OS
OS according to Subgroup
PFS
ORR
SUBSEQUENT TREATMENT POST DISCONTINUATION
SAFETY
SUMMARY

References:

  1. Keytruda Summary of Product Characteristics.
  2. Rini BI, Plimack ER, Stus V, et al; for the KEYNOTE-426 investigators. Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 2019; 380 (12): 1116–1127.

AE-RCC-00004 | Exp : 06 JUN 2024
AE-RCC-00003 | Exp : 06 JUN 2024
QA-RCC-00001 | Exp : 06 JUN 2024

OS
PFS
ORR
SUMMARY

References:

  1. Keytruda Summary of Product Characteristics.
  2. ASCO 2023: Pembrolizumab (Pembro) plus axitinib (AXI) versus sunitinib as first-line therapy for advanced clear cell renal cell carcinoma (ccrcc): Results of 5 years follow-up of keynote-426 (no date) UroToday. Available at: https://www.urotoday.com/conference-highlights/asco-2023/asco-2023-kidney-cancer/144965-asco-2023-pembrolizumab-axitinib-versus-sunitinib-as-first-line-therapy-for-advanced-clear-cell-rcc-5-year-analysis-of-keynote-426.html (Accessed: 20 August 2023).

AE-RCC-00004 | Exp : 06 JUN 2024
AE-RCC-00003 | Exp : 06 JUN 2024
QA-RCC-00001 | Exp : 06 JUN 2024

References:

  1. Keytruda Summary of Product Characteristics.
  2. Inlyta [SmPC]. Belgium: Pfizer Europe MA EEIG; 2021

AE-RCC-00004 | Exp : 06 JUN 2024
AE-RCC-00003 | Exp : 06 JUN 2024
QA-RCC-00001 | Exp : 06 JUN 2024

References:

  1. Keytruda Summary of Product Characteristics.
  2. Pardoll, D. M. (2012). The blockade of immune checkpoints in cancer immunotherapy. Nature Reviews Cancer, 12(4),252–264.
    https://doi.org/10.1038/nrc3239.
  3. Inlyta [SmPC]. Belgium: Pfizer Europe MA EEIG; 2021

AE-RCC-00004 | Exp : 06 JUN 2024
AE-RCC-00003 | Exp : 06 JUN 2024
QA-RCC-00001 | Exp : 06 JUN 2024

EAU
ESMO
NCCN
SITC

References:

  1. Keytruda Summary of Product Characteristics.
  2. Powles, T., Albiges, L., Bex, A., Grünwald, V., Porta, C.,. (2021). ESMO clinical practice guideline update on the use of immunotherapy in early stage and advanced renal cell carcinoma. Annals of Oncology, 32(12), 1511–1519.
    https://doi.org/10.1016/j.annonc.2021.09.014

AE-RCC-00004 | Exp : 06 JUN 2024
AE-RCC-00003 | Exp : 06 JUN 2024
QA-RCC-00001 | Exp : 06 JUN 2024